1iiu

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Revision as of 15:18, 20 November 2007

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spinqualitylabelsall models 1iiu, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Chicken plasma retinol-binding protein (RBP)

Overview

The crystal structure of the specific carrier of retinol (retinol-binding, protein, RBP) purified from chicken plasma has been determined (space, group P2(1)2(1)2(1), with a=46.06(5) A, b=53.56(6) A, c=73.41(8) A, and, one protein molecule in the asymmetric unit). Despite being obtained from, a species phylogenetically distant from mammals, chicken holoRBP has an, overall structure that closely resembles the previously determined, structures of mammalian holoRBPs. The lack in chicken RBP of eight, carboxy-terminal amino acid residues characteristic of mammalian RBPs does, not significantly affect the protein structure. A distinctive feature of, the avian protein is a better definition of the loop 63-67, close to the, opening of the beta-barrel cavity accommodating the retinol molecule, which is rather disordered in the structures of mammalian RBPs.

About this Structure

1IIU is a Single protein structure of sequence from Gallus gallus with CD and RTL as ligands. Full crystallographic information is available from OCA.

Reference

Structure of chicken plasma retinol-binding protein., Zanotti G, Calderone V, Beda M, Malpeli G, Folli C, Berni R, Biochim Biophys Acta. 2001 Nov 26;1550(1):64-9. PMID:11738088

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