1mi5

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[[Image:1mi5.gif|left|200px]]
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{{STRUCTURE_1mi5| PDB=1mi5 | SCENE= }}
{{STRUCTURE_1mi5| PDB=1mi5 | SCENE= }}
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'''The crystal structure of LC13 TcR in complex with HLAB8-EBV peptide complex'''
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===The crystal structure of LC13 TcR in complex with HLAB8-EBV peptide complex===
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==Overview==
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We have examined the basis for immunodominant or "public" TCR usage in an antiviral CTL response. Residues encoded by each of the highly selected genetic elements of an immunodominant clonotype recognizing Epstein-Barr virus were critical to the antigen specificity of the receptor. Upon recognizing antigen, the immunodominant TCR undergoes extensive conformational changes in the complementarity determining regions (CDRs), including the disruption of the canonical structures of the germline-encoded CDR1alpha and CDR2alpha loops to produce an enhanced fit with the HLA-peptide complex. TCR ligation induces conformational changes in the TCRalpha constant domain thought to form part of the docking site for CD3epsilon. These findings indicate that TCR immunodominance is associated with structural properties conferring receptor specificity and suggest a novel structural link between TCR ligation and intracellular signaling.
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(as it appears on PubMed at http://www.pubmed.gov), where 12530975 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12530975}}
==About this Structure==
==About this Structure==
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[[Category: Hla b8]]
[[Category: Hla b8]]
[[Category: T cell receptor]]
[[Category: T cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:05:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:01:19 2008''

Revision as of 21:01, 2 July 2008

Image:1mi5.png

Template:STRUCTURE 1mi5

The crystal structure of LC13 TcR in complex with HLAB8-EBV peptide complex

Template:ABSTRACT PUBMED 12530975

About this Structure

1MI5 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity., Kjer-Nielsen L, Clements CS, Purcell AW, Brooks AG, Whisstock JC, Burrows SR, McCluskey J, Rossjohn J, Immunity. 2003 Jan;18(1):53-64. PMID:12530975

Page seeded by OCA on Thu Jul 3 00:01:19 2008

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