1iiz
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(New page: 200px<br /><applet load="1iiz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1iiz, resolution 2.40Å" /> '''Crystal Structure of...)
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Revision as of 15:18, 20 November 2007
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Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta
Overview
The crystal structure of an antibacterial protein of immune origin, (TSWAB), purified from tasar silkworm (Antheraea mylitta) larvae after, induction by Escherichia coli infection, has been determined. This is the, first insect lysozyme structure and represents induced lysozymes of innate, immunity. The core structure of TSWAB is similar to c-type lysozymes and, alpha-lactalbumins. However, TSWAB shows significant differences with, respect to the other two proteins in the exposed loop regions. The, catalytic residues in TSWAB are conserved with respect to the chicken, lysozyme, indicating a common mechanism of action. However, differences in, the noncatalytic residues in the substrate binding groove imply subtle, differences in the specificity and the level of activity. Thus, conformational differences between TSWAB and chicken lysozyme exist, whereas functional mechanisms appear to be similar. On the other hand, alpha-lactalbumins and c-type lysozymes exhibit drastically different, functions with conserved molecular conformation. It is evident that a, common molecular scaffold is exploited in the three enzymes for apparently, different physiological roles. It can be inferred on the basis of the, structure-function comparison of these three proteins having common, phylogenetic origin that the conformational changes in a protein are, minimal during rapid evolution as compared with those in the normal course, of evolution.
About this Structure
1IIZ is a Single protein structure of sequence from Antheraea mylitta. Active as Lysozyme, with EC number 3.2.1.17 Full crystallographic information is available from OCA.
Reference
Structure of the induced antibacterial protein from tasar silkworm, Antheraea mylitta. Implications to molecular evolution., Jain D, Nair DT, Swaminathan GJ, Abraham EG, Nagaraju J, Salunke DM, J Biol Chem. 2001 Nov 2;276(44):41377-82. Epub 2001 Aug 24. PMID:11522783
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