1miu

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[[Image:1miu.gif|left|200px]]
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{{Seed}}
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[[Image:1miu.png|left|200px]]
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{{STRUCTURE_1miu| PDB=1miu | SCENE= }}
{{STRUCTURE_1miu| PDB=1miu | SCENE= }}
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'''Structure of a BRCA2-DSS1 complex'''
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===Structure of a BRCA2-DSS1 complex===
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==Overview==
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Mutations in the BRCA2 (breast cancer susceptibility gene 2) tumor suppressor lead to chromosomal instability due to defects in the repair of double-strand DNA breaks (DSBs) by homologous recombination, but BRCA2's role in this process has been unclear. Here, we present the 3.1 angstrom crystal structure of a approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif. We also (i) demonstrate that this BRCA2 domain binds single-stranded DNA, (ii) present its 3.5 angstrom structure bound to oligo(dT)9, (iii) provide data that implicate the HTH motif in dsDNA binding, and (iv) show that BRCA2 stimulates RAD51-mediated recombination in vitro. These findings establish that BRCA2 functions directly in homologous recombination and provide a structural and biochemical basis for understanding the loss of recombination-mediated DSB repair in BRCA2-associated cancers.
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The line below this paragraph, {{ABSTRACT_PUBMED_12228710}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12228710 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12228710}}
==About this Structure==
==About this Structure==
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[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Tumor suppressor]]
[[Category: Tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:07:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:03:56 2008''

Revision as of 21:04, 2 July 2008

Image:1miu.png

Template:STRUCTURE 1miu

Structure of a BRCA2-DSS1 complex

Template:ABSTRACT PUBMED 12228710

About this Structure

1MIU is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure., Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP, Science. 2002 Sep 13;297(5588):1837-48. PMID:12228710

Page seeded by OCA on Thu Jul 3 00:03:56 2008

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