1mj4

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{{STRUCTURE_1mj4| PDB=1mj4 | SCENE= }}
{{STRUCTURE_1mj4| PDB=1mj4 | SCENE= }}
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'''Crystal Structure Analysis of the cytochrome b5 domain of human sulfite oxidase'''
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===Crystal Structure Analysis of the cytochrome b5 domain of human sulfite oxidase===
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==Overview==
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The molybdenum- and iron-containing enzyme sulfite oxidase catalyzes the physiologically vital oxidation of sulfite to sulfate. Sulfite oxidase contains three domains: an N-terminal cytochrome b(5) domain, a central domain harboring the molybdenum cofactor (Moco) and a C-terminal dimerization domain. Oxidation of the substrate sulfite is coupled to the transfer of two electrons to the molybdenum cofactor. Subsequently, these electrons are passed on, one at a time, to the b(5) heme of sulfite oxidase and from there to the soluble electron carrier cytochrome c. The crystal structure of the oxidized human sulfite oxidase cytochrome b(5) domain has been determined at 1.2 A resolution and has been refined to a crystallographic R factor of 0.107 (R(free) = 0.137). A comparison of this structure with other b(5)-type cytochromes reveals distinct structural features present in the sulfite oxidase b(5) domain which promote optimal electron transport between the Moco of sulfite oxidase and the heme of cytochrome c.
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{{ABSTRACT_PUBMED_12832761}}
==About this Structure==
==About this Structure==
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[[Category: Heme]]
[[Category: Heme]]
[[Category: Sulfite oxidase]]
[[Category: Sulfite oxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:09:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:05:19 2008''

Revision as of 21:05, 2 July 2008

Image:1mj4.png

Template:STRUCTURE 1mj4

Crystal Structure Analysis of the cytochrome b5 domain of human sulfite oxidase

Template:ABSTRACT PUBMED 12832761

About this Structure

1MJ4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain., Rudolph MJ, Johnson JL, Rajagopalan KV, Kisker C, Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1183-91. Epub 2003, Jun 27. PMID:12832761

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