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1mjd

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{{STRUCTURE_1mjd| PDB=1mjd | SCENE= }}
{{STRUCTURE_1mjd| PDB=1mjd | SCENE= }}
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'''Structure of N-terminal domain of human doublecortin'''
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===Structure of N-terminal domain of human doublecortin===
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==Overview==
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The doublecortin-like domains (DCX), which typically occur in tandem, are novel microtubule-binding modules. DCX tandems are found in doublecortin, a 360-residue protein expressed in migrating neurons; the doublecortin-like kinase (DCLK); the product of the RP1 gene that is responsible for a form of inherited blindness; and several other proteins. Mutations in the gene encoding doublecortin cause lissencephaly in males and the 'double-cortex syndrome' in females. We here report a solution structure of the N-terminal DCX domain of human doublecortin and a 1.5 A resolution crystal structure of the equivalent domain from human DCLK. Both show a stable, ubiquitin-like tertiary fold with distinct structural similarities to GTPase-binding domains. We also show that the C-terminal DCX domains of both proteins are only partially folded. In functional assays, the N-terminal DCX domain of doublecortin binds only to assembled microtubules, whereas the C-terminal domain binds to both microtubules and unpolymerized tubulin.
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(as it appears on PubMed at http://www.pubmed.gov), where 12692530 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12692530}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1MJD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJD OCA].
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1MJD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJD OCA].
==Reference==
==Reference==
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[[Category: Microtubule associated protein]]
[[Category: Microtubule associated protein]]
[[Category: Ubiquitin-like fold]]
[[Category: Ubiquitin-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:10:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:06:20 2008''

Revision as of 21:06, 2 July 2008

Image:1mjd.png

Template:STRUCTURE 1mjd

Contents

Structure of N-terminal domain of human doublecortin

Template:ABSTRACT PUBMED 12692530

Disease

Known disease associated with this structure: Lissencephaly, X-linked OMIM:[300121], Subcortical laminal heteropia, X-linked OMIM:[300121]

About this Structure

1MJD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The DCX-domain tandems of doublecortin and doublecortin-like kinase., Kim MH, Cierpicki T, Derewenda U, Krowarsch D, Feng Y, Devedjiev Y, Dauter Z, Walsh CA, Otlewski J, Bushweller JH, Derewenda ZS, Nat Struct Biol. 2003 May;10(5):324-33. PMID:12692530

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