1mk0

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{{STRUCTURE_1mk0| PDB=1mk0 | SCENE= }}
{{STRUCTURE_1mk0| PDB=1mk0 | SCENE= }}
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'''catalytic domain of intron endonuclease I-TevI, E75A mutant'''
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===catalytic domain of intron endonuclease I-TevI, E75A mutant===
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==Overview==
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I-TevI, a member of the GIY-YIG family of homing endonucleases, consists of an N-terminal catalytic domain and a C-terminal DNA-binding domain joined by a flexible linker. The GIY-YIG motif is in the N-terminal domain of I-TevI, which corresponds to a phylogenetically widespread catalytic cartridge that is often associated with mobile genetic elements. The crystal structure of the catalytic domain of I-TevI, the first of any GIY-YIG endonuclease, reveals a novel alpha/beta-fold with a central three-stranded antiparallel beta-sheet flanked by three helices. The most conserved and putative catalytic residues are located on a shallow, concave surface and include a metal coordination site. Similarities in the three-dimensional arrangement of the catalytically important residues and the cation-binding site with those of the His-Cys box endonuclease I-PpoI suggest the possibility of mechanistic relationships among these different families of homing endonucleases despite completely different folds.
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(as it appears on PubMed at http://www.pubmed.gov), where 12379841 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12379841}}
==About this Structure==
==About this Structure==
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[[Category: Catalytic domain]]
[[Category: Catalytic domain]]
[[Category: Dna-binding surface]]
[[Category: Dna-binding surface]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:15:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:09:00 2008''

Revision as of 21:09, 2 July 2008

Image:1mk0.png

Template:STRUCTURE 1mk0

catalytic domain of intron endonuclease I-TevI, E75A mutant

Template:ABSTRACT PUBMED 12379841

About this Structure

1MK0 is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Catalytic domain structure and hypothesis for function of GIY-YIG intron endonuclease I-TevI., Van Roey P, Meehan L, Kowalski JC, Belfort M, Derbyshire V, Nat Struct Biol. 2002 Nov;9(11):806-11. PMID:12379841

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