1mke

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[[Image:1mke.jpg|left|200px]]
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{{Seed}}
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[[Image:1mke.png|left|200px]]
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{{STRUCTURE_1mke| PDB=1mke | SCENE= }}
{{STRUCTURE_1mke| PDB=1mke | SCENE= }}
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'''Structure of the N-WASP EVH1 Domain-WIP complex'''
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===Structure of the N-WASP EVH1 Domain-WIP complex===
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==Overview==
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Missense mutants that cause the immune disorder Wiskott-Aldrich Syndrome (WAS) map primarily to the Enabled/VASP homology 1 (EVH1) domain of the actin regulatory protein WASP. This domain has been implicated in both peptide and phospholipid binding. We show here that the N-WASP EVH1 domain does not bind phosphatidyl inositol-(4,5)-bisphosphate, as previously reported, but does specifically bind a 25 residue motif from the WASP Interacting Protein (WIP). The NMR structure of the complex reveals a novel recognition mechanism-the WIP ligand, which is far longer than canonical EVH1 ligands, wraps around the domain, contacting a narrow but extended surface. This recognition mechanism provides a basis for understanding the effects of mutations that cause WAS.
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The line below this paragraph, {{ABSTRACT_PUBMED_12437929}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12437929 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12437929}}
==About this Structure==
==About this Structure==
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1MKE is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MKE OCA].
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1MKE is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MKE OCA].
==Reference==
==Reference==
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[[Category: Polyproline]]
[[Category: Polyproline]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:17:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:10:41 2008''

Revision as of 21:10, 2 July 2008

Image:1mke.png

Template:STRUCTURE 1mke

Structure of the N-WASP EVH1 Domain-WIP complex

Template:ABSTRACT PUBMED 12437929

About this Structure

1MKE is a Single protein structure. Full experimental information is available from OCA.

Reference

Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome., Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA, Cell. 2002 Nov 15;111(4):565-76. PMID:12437929

Page seeded by OCA on Thu Jul 3 00:10:41 2008

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