1ml9

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[[Image:1ml9.gif|left|200px]]
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{{STRUCTURE_1ml9| PDB=1ml9 | SCENE= }}
{{STRUCTURE_1ml9| PDB=1ml9 | SCENE= }}
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'''Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase'''
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===Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase===
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==Overview==
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AdoMet-dependent methylation of histones is part of the "histone code" that can profoundly influence gene expression. We describe the crystal structure of Neurospora DIM-5, a histone H3 lysine 9 methyltranferase (HKMT), determined at 1.98 A resolution, as well as results of biochemical characterization and site-directed mutagenesis of key residues. This SET domain protein bears no structural similarity to previously characterized AdoMet-dependent methyltransferases but includes notable features such as a triangular Zn3Cys9 zinc cluster in the pre-SET domain and a AdoMet binding site in the SET domain essential for methyl transfer. The structure suggests a mechanism for the methylation reaction and provides the structural basis for functional characterization of the HKMT family and the SET domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 12372305 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12372305}}
==About this Structure==
==About this Structure==
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[[Category: Adomet-dependent methyltransferase histone h3 lysine-9 methylation]]
[[Category: Adomet-dependent methyltransferase histone h3 lysine-9 methylation]]
[[Category: Dim-5]]
[[Category: Dim-5]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:22:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:15:20 2008''

Revision as of 21:15, 2 July 2008

Image:1ml9.png

Template:STRUCTURE 1ml9

Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase

Template:ABSTRACT PUBMED 12372305

About this Structure

1ML9 is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

Reference

Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase., Zhang X, Tamaru H, Khan SI, Horton JR, Keefe LJ, Selker EU, Cheng X, Cell. 2002 Oct 4;111(1):117-27. PMID:12372305

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