1mo8

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[[Image:1mo8.gif|left|200px]]
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{{STRUCTURE_1mo8| PDB=1mo8 | SCENE= }}
{{STRUCTURE_1mo8| PDB=1mo8 | SCENE= }}
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'''ATPase'''
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===ATPase===
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==Overview==
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The Na,K-ATPase hydrolyzes ATP to drive the coupled extrusion and uptake of Na+ and K+ ions across the plasma membrane. Here, we report two high-resolution NMR structures of the 213-residue nucleotide-binding domain of rat alpha1 Na,K-ATPase, determined in the absence and the presence of ATP. The nucleotide binds in the anti conformation and shows a relative paucity of interactions with the protein, reflecting the low-affinity ATP-binding state. Binding of ATP induces substantial conformational changes in the binding pocket and in residues located in the hinge region connecting the N- and P-domains. Structural comparison with the Ca-ATPase stabilized by the inhibitor thapsigargin, E2(TG), and the model of the H-ATPase in the E1 form suggests that the observed changes may trigger the series of events necessary for the release of the K+ ions and/or disengagement of the A-domain, leading to the eventual transfer of the gamma-phosphate group to the invariant Asp369.
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{{ABSTRACT_PUBMED_12730684}}
==About this Structure==
==About this Structure==
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1MO8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO8 OCA].
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1MO8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO8 OCA].
==Reference==
==Reference==
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[[Category: Six-stranded]]
[[Category: Six-stranded]]
[[Category: Twisted beta sheet]]
[[Category: Twisted beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:30:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:32:31 2008''

Revision as of 21:32, 2 July 2008

Image:1mo8.png

Template:STRUCTURE 1mo8

ATPase

Template:ABSTRACT PUBMED 12730684

About this Structure

1MO8 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase., Hilge M, Siegal G, Vuister GW, Guntert P, Gloor SM, Abrahams JP, Nat Struct Biol. 2003 Jun;10(6):468-74. PMID:12730684

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