1mpo

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{{STRUCTURE_1mpo| PDB=1mpo | SCENE= }}
{{STRUCTURE_1mpo| PDB=1mpo | SCENE= }}
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'''MALTOPORIN MALTOHEXAOSE COMPLEX'''
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===MALTOPORIN MALTOHEXAOSE COMPLEX===
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==Overview==
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BACKGROUND: Maltoporin (which is encoded by the lamB gene) facilitates the translocation of maltodextrins across the outer membrane of E. coli. In particular, it is indispensable for the transport of long maltooligosaccharides, as these do not pass through non-specific porins. An understanding of this intriguing capability requires elucidation of the structural basis. RESULTS: The crystal structures of maltoporin in complex with maltose, maltotriose and maltohexaose reveal an extended binding site within the maltoporin channel. The maltooligosaccharides are in apolar van der Waals contact with the 'greasy slide', a hydrophobic path that is composed of aromatic residues and located at the channel lining. At the constriction of the channel the sugars are tightly surrounded by protein side chains and form an extensive hydrogen-bonding network with ionizable amino-acid residues. CONCLUSION: Hydrophobic interactions with the greasy slide guide the sugar into and through the channel constriction. The glucosyl-binding subsites at the channel constriction confer stereospecificity to the channel along with the ability to scavenge substrate at low concentrations.
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(as it appears on PubMed at http://www.pubmed.gov), where 8805519 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8805519}}
==About this Structure==
==About this Structure==
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[[Category: Specific porin]]
[[Category: Specific porin]]
[[Category: Sugar transport]]
[[Category: Sugar transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:43:14 2008''

Revision as of 21:43, 2 July 2008

Image:1mpo.png

Template:STRUCTURE 1mpo

MALTOPORIN MALTOHEXAOSE COMPLEX

Template:ABSTRACT PUBMED 8805519

About this Structure

1MPO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway., Dutzler R, Wang YF, Rizkallah P, Rosenbusch JP, Schirmer T, Structure. 1996 Feb 15;4(2):127-34. PMID:8805519

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