1mpu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mpu.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1mpu.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mpu| PDB=1mpu | SCENE= }}
{{STRUCTURE_1mpu| PDB=1mpu | SCENE= }}
-
'''Crystal Structure of the free human NKG2D immunoreceptor'''
+
===Crystal Structure of the free human NKG2D immunoreceptor===
-
==Overview==
+
<!--
-
Engagement of diverse protein ligands (MIC-A/B, ULBP, Rae-1, or H60) by NKG2D immunoreceptors mediates elimination of tumorigenic or virally infected cells by natural killer and T cells. Three previous NKG2D-ligand complex structures show the homodimeric receptor interacting with the monomeric ligands in similar 2:1 complexes, with an equivalent surface on each NKG2D monomer binding intimately to a total of six distinct ligand surfaces. Here, the crystal structure of free human NKG2D and in silico and in vitro alanine-scanning mutagenesis analyses of the complex interfaces indicate that NKG2D recognition degeneracy is not explained by a classical induced-fit mechanism. Rather, the divergent ligands appear to utilize different strategies to interact with structurally conserved elements of the consensus NKG2D binding site.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12679019}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12679019 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12679019}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Strong, R K.]]
[[Category: Strong, R K.]]
[[Category: C-type lectin-like domain]]
[[Category: C-type lectin-like domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:16 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:45:15 2008''

Revision as of 21:45, 2 July 2008

Image:1mpu.png

Template:STRUCTURE 1mpu

Crystal Structure of the free human NKG2D immunoreceptor

Template:ABSTRACT PUBMED 12679019

About this Structure

1MPU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands., McFarland BJ, Kortemme T, Yu SF, Baker D, Strong RK, Structure. 2003 Apr;11(4):411-22. PMID:12679019

Page seeded by OCA on Thu Jul 3 00:45:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mpu"
Personal tools