1mpv

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[[Image:1mpv.gif|left|200px]]
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{{Seed}}
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[[Image:1mpv.png|left|200px]]
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{{STRUCTURE_1mpv| PDB=1mpv | SCENE= }}
{{STRUCTURE_1mpv| PDB=1mpv | SCENE= }}
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'''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide'''
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===Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide===
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==Overview==
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The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF.
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The line below this paragraph, {{ABSTRACT_PUBMED_12387744}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12387744 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12387744}}
==About this Structure==
==About this Structure==
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1MPV is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
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1MPV is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
==Reference==
==Reference==
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[[Category: Yin, J.]]
[[Category: Yin, J.]]
[[Category: Beta-hairpin]]
[[Category: Beta-hairpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:45:27 2008''

Revision as of 21:45, 2 July 2008

Image:1mpv.png

Template:STRUCTURE 1mpv

Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide

Template:ABSTRACT PUBMED 12387744

About this Structure

1MPV is a Single protein structure. Full experimental information is available from OCA.

Reference

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:12387744

Page seeded by OCA on Thu Jul 3 00:45:27 2008

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