1mqa

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[[Image:1mqa.jpg|left|200px]]
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{{STRUCTURE_1mqa| PDB=1mqa | SCENE= }}
{{STRUCTURE_1mqa| PDB=1mqa | SCENE= }}
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'''Crystal structure of high affinity alphaL I domain in the absence of ligand or metal'''
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===Crystal structure of high affinity alphaL I domain in the absence of ligand or metal===
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==Overview==
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The structure of the I domain of integrin alpha L beta 2 bound to the Ig superfamily ligand ICAM-1 reveals the open ligand binding conformation and the first example of an integrin-IgSF interface. The I domain Mg2+ directly coordinates Glu-34 of ICAM-1, and a dramatic swing of I domain residue Glu-241 enables a critical salt bridge. Liganded and unliganded structures for both high- and intermediate-affinity mutant I domains reveal that ligand binding can induce conformational change in the alpha L I domain and that allosteric signals can convert the closed conformation to intermediate or open conformations without ligand binding. Pulling down on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in affinity.
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The line below this paragraph, {{ABSTRACT_PUBMED_12526797}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12526797 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12526797}}
==About this Structure==
==About this Structure==
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[[Category: Designed disulfide bridge]]
[[Category: Designed disulfide bridge]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:35:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:52:04 2008''

Revision as of 21:52, 2 July 2008

Image:1mqa.png

Template:STRUCTURE 1mqa

Crystal structure of high affinity alphaL I domain in the absence of ligand or metal

Template:ABSTRACT PUBMED 12526797

About this Structure

1MQA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation., Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA, Cell. 2003 Jan 10;112(1):99-111. PMID:12526797

Page seeded by OCA on Thu Jul 3 00:52:04 2008

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