3hts

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{{STRUCTURE_3hts| PDB=3hts | SCENE= }}
{{STRUCTURE_3hts| PDB=3hts | SCENE= }}
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'''HEAT SHOCK TRANSCRIPTION FACTOR/DNA COMPLEX'''
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===HEAT SHOCK TRANSCRIPTION FACTOR/DNA COMPLEX===
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==Overview==
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The 1.75 A crystal structure of the Kluyveromyces lactis heat shock transcription factor (HSF) DNA-binding domain (DBD) complexed with DNA reveals a protein-DNA interface with few direct major groove contacts and a number of phosphate backbone contacts that are primarily water-mediated interactions. The DBD, a 'winged' helix-turn-helix protein, displays a novel mode of binding in that the 'wing' does not contact DNA like all others of that class. Instead, the monomeric DBD, which crystallized as a symmetric dimer to a pair of nGAAn inverted repeats, uses the 'wing' to form part of the protein-protein contacts. This dimer interface is likely important for increasing the DNA-binding specificity and affinity of the trimeric form of HSF, as well as for increasing cooperativity between adjacent trimers.
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(as it appears on PubMed at http://www.pubmed.gov), where 10331875 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10331875}}
==About this Structure==
==About this Structure==
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[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:04:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 12:50:05 2008''

Revision as of 09:50, 3 July 2008

Image:3hts.png

Template:STRUCTURE 3hts

HEAT SHOCK TRANSCRIPTION FACTOR/DNA COMPLEX

Template:ABSTRACT PUBMED 10331875

About this Structure

3HTS is a Single protein structure of sequence from Kluyveromyces lactis. Full crystallographic information is available from OCA.

Reference

A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal., Littlefield O, Nelson HC, Nat Struct Biol. 1999 May;6(5):464-70. PMID:10331875

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