3hvp

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{{Seed}}
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{{STRUCTURE_3hvp| PDB=3hvp | SCENE= }}
{{STRUCTURE_3hvp| PDB=3hvp | SCENE= }}
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'''CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE'''
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===CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE===
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==Overview==
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The rational design of drugs that can inhibit the action of viral proteases depends on obtaining accurate structures of these enzymes. The crystal structure of chemically synthesized HIV-1 protease has been determined at 2.8 angstrom resolution (R factor of 0.184) with the use of a model based on the Rous sarcoma virus protease structure. In this enzymatically active protein, the cysteines were replaced by alpha-amino-n-butyric acid, a nongenetically coded amino acid. This structure, in which all 99 amino acids were located, differs in several important details from that reported previously by others. The interface between the identical subunits forming the active protease dimer is composed of four well-ordered beta strands from both the amino and carboxyl termini and residues 86 to 94 have a helical conformation. The observed arrangement of the dimer interface suggests possible designs for dimerization inhibitors.
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The line below this paragraph, {{ABSTRACT_PUBMED_2548279}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 2548279 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2548279}}
==About this Structure==
==About this Structure==
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[[Category: Miller, M.]]
[[Category: Miller, M.]]
[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:04:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 12:50:19 2008''

Revision as of 09:50, 3 July 2008

Image:3hvp.png

Template:STRUCTURE 3hvp

CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE

Template:ABSTRACT PUBMED 2548279

About this Structure

3HVP is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease., Wlodawer A, Miller M, Jaskolski M, Sathyanarayana BK, Baldwin E, Weber IT, Selk LM, Clawson L, Schneider J, Kent SB, Science. 1989 Aug 11;245(4918):616-21. PMID:2548279

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