3icd

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{{Seed}}
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{{STRUCTURE_3icd| PDB=3icd | SCENE= }}
{{STRUCTURE_3icd| PDB=3icd | SCENE= }}
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'''STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE'''
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===STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE===
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==Overview==
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The structure of isocitrate dehydrogenase [threo-DS-isocitrate: NADP+ oxidoreductase (decarboxylating), EC 1.1.1.42] from Escherichia coli has been solved and refined at 2.5 A resolution and is topologically different from that of any other dehydrogenase. This enzyme, a dimer of identical 416-residue subunits, is inactivated by phosphorylation at Ser-113, which lies at the edge of an interdomain pocket that also contains many residues conserved between isocitrate dehydrogenase and isopropylmalate dehydrogenase. Isocitrate dehydrogenase contains an unusual clasp-like domain in which both polypeptide chains in the dimer interlock. Based on the structure of isocitrate dehydrogenase and conservation with isopropylmalate dehydrogenase, we suggest that the active site lies in an interdomain pocket close to the phosphorylation site.
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(as it appears on PubMed at http://www.pubmed.gov), where 2682654 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2682654}}
==About this Structure==
==About this Structure==
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[[Category: Stroud, R M.]]
[[Category: Stroud, R M.]]
[[Category: Thorsness, P E.]]
[[Category: Thorsness, P E.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:04:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 12:50:44 2008''

Revision as of 09:50, 3 July 2008

Image:3icd.png

Template:STRUCTURE 3icd

STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE

Template:ABSTRACT PUBMED 2682654

About this Structure

3ICD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase., Hurley JH, Thorsness PE, Ramalingam V, Helmers NH, Koshland DE Jr, Stroud RM, Proc Natl Acad Sci U S A. 1989 Nov;86(22):8635-9. PMID:2682654

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