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3lkf

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{{STRUCTURE_3lkf| PDB=3lkf | SCENE= }}
{{STRUCTURE_3lkf| PDB=3lkf | SCENE= }}
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'''LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS WITH PHOSPHOCHOLINE BOUND'''
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===LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS WITH PHOSPHOCHOLINE BOUND===
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==Overview==
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Staphylococcal LukF, LukS, HgammaII, and alpha-hemolysin are self-assembling, channel-forming proteins related in sequence and function. In the alpha-hemolysin heptamer, the channel-forming beta-strands and the amino latch make long excursions from the protomer core. Here we report the crystal structure of the water soluble form of LukF. In the LukF structure the channel-forming region folds into an amphipathic, three-strand beta-sheet and the amino latch forms a beta-strand extending a central beta-sheet. The LukF structure illustrates how a channel-forming toxin masks protein-protein and protein-membrane interfaces prior to cell binding and assembly, and together with the alpha-hemolysin heptamer structure, they define the end points on the pathway of toxin assembly.
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(as it appears on PubMed at http://www.pubmed.gov), where 10048924 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10048924}}
==About this Structure==
==About this Structure==
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[[Category: Leukotoxin]]
[[Category: Leukotoxin]]
[[Category: Pore-forming toxin]]
[[Category: Pore-forming toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:05:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 12:53:35 2008''

Revision as of 09:53, 3 July 2008

Image:3lkf.png

Template:STRUCTURE 3lkf

LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS WITH PHOSPHOCHOLINE BOUND

Template:ABSTRACT PUBMED 10048924

About this Structure

3LKF is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel., Olson R, Nariya H, Yokota K, Kamio Y, Gouaux E, Nat Struct Biol. 1999 Feb;6(2):134-40. PMID:10048924

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