3pjr

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{{STRUCTURE_3pjr| PDB=3pjr | SCENE= }}
{{STRUCTURE_3pjr| PDB=3pjr | SCENE= }}
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'''HELICASE SUBSTRATE COMPLEX'''
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===HELICASE SUBSTRATE COMPLEX===
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==Overview==
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We have determined two different structures of PcrA DNA helicase complexed with the same single strand tailed DNA duplex, providing snapshots of different steps on the catalytic pathway. One of the structures is of a complex with a nonhydrolyzable analog of ATP and is thus a "substrate" complex. The other structure contains a bound sulphate ion that sits in a position equivalent to that occupied by the phosphate ion produced after ATP hydrolysis, thereby mimicking a "product" complex. In both complexes, the protein is monomeric. Large and distinct conformational changes occur on binding DNA and the nucleotide cofactor. Taken together, these structures provide evidence against an "active rolling" model for helicase action but are instead consistent with an "inchworm" mechanism.
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{{ABSTRACT_PUBMED_10199404}}
==About this Structure==
==About this Structure==
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[[Category: Wigley, D B.]]
[[Category: Wigley, D B.]]
[[Category: Helicase]]
[[Category: Helicase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:02:34 2008''

Revision as of 10:02, 3 July 2008

Image:3pjr.png


PDB ID 3pjr

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3pjr, resolution 3.30Å ()
Ligands:
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



HELICASE SUBSTRATE COMPLEX

Template:ABSTRACT PUBMED 10199404

About this Structure

3PJR is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism., Velankar SS, Soultanas P, Dillingham MS, Subramanya HS, Wigley DB, Cell. 1999 Apr 2;97(1):75-84. PMID:10199404

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