1irx

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(New page: 200px<br /><applet load="1irx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1irx, resolution 2.6&Aring;" /> '''Crystal structure of ...)
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Revision as of 15:29, 20 November 2007

Image:1irx.gif

1irx, resolution 2.6Å

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Crystal structure of class I lysyl-tRNA synthetase

Overview

Lysyl-tRNA can be synthesized by both a class I (LysRS-I) and a class II, (LysRS-II) lysyl-tRNA synthetase. The crystal structure of LysRS-I from, Pyrococcus horikoshii at 2.6 A resolution reveals extensive similarity, with glutamyl-tRNA synthetase (GluRS). A comparison of the structures of, LysRS-I and LysRS-II in complex with lysine shows that both enzymes use, similar strategies for substrate recognition within unrelated active site, topologies. A docking model based upon the GluRS-tRNA complex suggests how, LysRS-I and LysRS-II can recognize the same molecular determinants in, tRNALys, as shown by biochemical results, while approaching the acceptor, helix of the tRNA from opposite sides.

About this Structure

1IRX is a Single protein structure of sequence from Pyrococcus horikoshii with ZN as ligand. Active as Lysine--tRNA ligase, with EC number 6.1.1.6 Full crystallographic information is available from OCA.

Reference

Functional convergence of two lysyl-tRNA synthetases with unrelated topologies., Terada T, Nureki O, Ishitani R, Ambrogelly A, Ibba M, Soll D, Yokoyama S, Nat Struct Biol. 2002 Apr;9(4):257-62. PMID:11887185

Page seeded by OCA on Tue Nov 20 17:37:03 2007

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