3sgb

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{{STRUCTURE_3sgb| PDB=3sgb | SCENE= }}
{{STRUCTURE_3sgb| PDB=3sgb | SCENE= }}
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'''STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEASE B AND THE THIRD DOMAIN OF THE TURKEY OVOMUCOID INHIBITOR AT 1.8 ANGSTROMS RESOLUTION'''
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===STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEASE B AND THE THIRD DOMAIN OF THE TURKEY OVOMUCOID INHIBITOR AT 1.8 ANGSTROMS RESOLUTION===
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==Overview==
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The structure of the complex between the serine protease Streptomyces griseus protease B (SGPB) and the third domain of the Kazal-type ovomucoid inhibitor from turkey has been solved at 1.8-A resolution and refined to a conventional R factor of 0.125. As others have reported previously for analogous complexes of proteases and protein inhibitors, the inhibitor binds in a fashion similar to that of a substrate; it is not cleaved, but there is a close approach (2.7 A) of the active site nucleophile Ser-195 O gamma to the carbonyl carbon of the reactive peptide bond of the inhibitor. Contrary to the structural reports regarding the other enzyme-inhibitor complexes, we conclude that there is no evidence for a significant distortion of this peptide bond from planarity. The mechanism of inhibition can be understood in terms of the equilibrium thermodynamic parameters Ka, the enzyme-inhibitor association constant, and Khyd, the equilibrium constant for inhibitor hydrolysis. These thermodynamic parameters can be rationalized in terms of the observed structure.
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{{ABSTRACT_PUBMED_6414511}}
==About this Structure==
==About this Structure==
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[[Category: Read, R J.]]
[[Category: Read, R J.]]
[[Category: Sielecki, A R.]]
[[Category: Sielecki, A R.]]
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Revision as of 10:07, 3 July 2008

Image:3sgb.png

Template:STRUCTURE 3sgb

STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEASE B AND THE THIRD DOMAIN OF THE TURKEY OVOMUCOID INHIBITOR AT 1.8 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 6414511

About this Structure

3SGB is a Protein complex structure of sequences from Streptomyces griseus. This structure supersedes the now removed PDB entries and 1sgb. Full crystallographic information is available from OCA.

Reference

Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-A resolution., Read RJ, Fujinaga M, Sielecki AR, James MN, Biochemistry. 1983 Sep 13;22(19):4420-33. PMID:6414511

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