3sli

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3sli.gif|left|200px]]
+
{{Seed}}
 +
[[Image:3sli.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3sli| PDB=3sli | SCENE= }}
{{STRUCTURE_3sli| PDB=3sli | SCENE= }}
-
'''LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2,7-ANHYDRO-NEU5AC PREPARED BY SOAKING WITH 3'-SIALYLLACTOSE'''
+
===LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2,7-ANHYDRO-NEU5AC PREPARED BY SOAKING WITH 3'-SIALYLLACTOSE===
-
==Overview==
+
<!--
-
Intramolecular trans-sialidase from leech (Macrobdella decora) is the first member of the sialidase superfamily found to exhibit strict specificity towards the cleavage of terminal Neu5Acalpha2--&gt;3Gal linkage in sialoglycoconjugates. Its release of 2,7-anhydro-Neu5Ac instead of Neu5Ac indicates that it catalyzes an intramolecular trans-sialosyl reaction. Crystal structures of its complexes with an inactive substrate analogue 2-propenyl-Neu5Ac, and with the product 2,7-anhydro-Neu5Ac, have been determined to 1.8 A resolution. The boat conformation of the pyranose observed in the complexes supports the proposed enzymatic mechanism that O7 of an axial 6-glycerol group attacks the positively charged C2 of the intermediate. A generalized mechanism is proposed for the sialidase superfamily.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9878409}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9878409 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9878409}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Intramolecular trans-sialidase]]
[[Category: Intramolecular trans-sialidase]]
[[Category: Neuraminidase]]
[[Category: Neuraminidase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:13:16 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:07:25 2008''

Revision as of 10:07, 3 July 2008

Image:3sli.png

Template:STRUCTURE 3sli

LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2,7-ANHYDRO-NEU5AC PREPARED BY SOAKING WITH 3'-SIALYLLACTOSE

Template:ABSTRACT PUBMED 9878409

About this Structure

3SLI is a Single protein structure of sequence from Macrobdella decora. Full crystallographic information is available from OCA.

Reference

The 1.8 A structures of leech intramolecular trans-sialidase complexes: evidence of its enzymatic mechanism., Luo Y, Li SC, Li YT, Luo M, J Mol Biol. 1999 Jan 8;285(1):323-32. PMID:9878409

Page seeded by OCA on Thu Jul 3 13:07:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3sli"
Personal tools