3sxl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3sxl.gif|left|200px]]
+
{{Seed}}
 +
[[Image:3sxl.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3sxl| PDB=3sxl | SCENE= }}
{{STRUCTURE_3sxl| PDB=3sxl | SCENE= }}
-
'''SEX-LETHAL RNA RECOGNITION DOMAINS 1 AND 2 FROM DROSOPHILA MELANOGASTER'''
+
===SEX-LETHAL RNA RECOGNITION DOMAINS 1 AND 2 FROM DROSOPHILA MELANOGASTER===
-
==Overview==
+
<!--
-
By binding specific RNA transcripts, the Sex-lethal protein (SXL) governs sexual differentiation and dosage compensation in Drosophila melanogaster. To investigate the basis for RNA binding specificity, we determined the crystal structure of the tandem RNA recognition motifs (RRMs) of SXL. Both RRMs adopt the canonical RRM fold, and the 10-residue, interdomain linker shows significant disorder. In contrast to the previously determined structure of the two-RRM fragment of heterogeneous nuclear ribonucleoprotein Al, SXL displays no interdomain contacts between RRMs. These results suggest that the SXL RRMs are flexibly tethered in solution, and RNA binding restricts the orientation of RRMs. Therefore, the observed specificity for single-stranded, U-rich sequences does not arise from a predefined, rigid architecture of the isolated SXL RRMs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10220389}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10220389 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10220389}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Translational inhibitor]]
[[Category: Translational inhibitor]]
[[Category: X chromosome dosage compensation]]
[[Category: X chromosome dosage compensation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:13:36 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:08:06 2008''

Revision as of 10:08, 3 July 2008

Image:3sxl.png

Template:STRUCTURE 3sxl

SEX-LETHAL RNA RECOGNITION DOMAINS 1 AND 2 FROM DROSOPHILA MELANOGASTER

Template:ABSTRACT PUBMED 10220389

About this Structure

3SXL is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal., Crowder SM, Kanaar R, Rio DC, Alber T, Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4892-7. PMID:10220389

Page seeded by OCA on Thu Jul 3 13:08:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3sxl"
Personal tools