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437d

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[[Image:437d.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_437d| PDB=437d | SCENE= }}
{{STRUCTURE_437d| PDB=437d | SCENE= }}
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'''CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING'''
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===CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING===
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==Overview==
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Many viruses regulate translation of polycistronic mRNA using a -1 ribosomal frameshift induced by an RNA pseudoknot. A pseudoknot has two stems that form a quasi-continuous helix and two connecting loops. A 1.6 A crystal structure of the beet western yellow virus (BWYV) pseudoknot reveals rotation and a bend at the junction of the two stems. A loop base is inserted in the major groove of one stem with quadruple-base interactions. The second loop forms a new minor-groove triplex motif with the other stem, involving 2'-OH and triple-base interactions, as well as sodium ion coordination. Overall, the number of hydrogen bonds stabilizing the tertiary interactions exceeds the number involved in Watson-Crick base pairs. This structure will aid mechanistic analyses of ribosomal frameshifting.
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The line below this paragraph, {{ABSTRACT_PUBMED_10074948}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10074948 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10074948}}
==About this Structure==
==About this Structure==
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[[Category: Triplex]]
[[Category: Triplex]]
[[Category: Viral frameshifting]]
[[Category: Viral frameshifting]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:17:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:19:31 2008''

Revision as of 10:19, 3 July 2008

Image:437d.png

Template:STRUCTURE 437d

CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING

Template:ABSTRACT PUBMED 10074948

About this Structure

Full crystallographic information is available from OCA.

Reference

Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot., Su L, Chen L, Egli M, Berger JM, Rich A, Nat Struct Biol. 1999 Mar;6(3):285-92. PMID:10074948

Page seeded by OCA on Thu Jul 3 13:19:31 2008

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