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467d

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[[Image:467d.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_467d| PDB=467d | SCENE= }}
{{STRUCTURE_467d| PDB=467d | SCENE= }}
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'''The structure of a decamer forming a four-way junction'''
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===The structure of a decamer forming a four-way junction===
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==Overview==
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DNA recombination is a universal biological event responsible both for the generation of genetic diversity and for the maintenance of genome integrity. A four-way DNA junction, also termed Holliday junction, is the key intermediate in nearly all recombination processes. This junction is the substrate of recombination enzymes that promote branch migration or catalyze its resolution. We have determined the crystal structure of a four-way DNA junction by multiwavelength anomalous diffraction, and refined it to 2.16 A resolution. The structure has two-fold symmetry, with pairwise stacking of the double-helical arms, which form two continuous B-DNA helices that run antiparallel, cross in a right-handed way, and contain two G-A mismatches. The exchanging backbones form a compact structure with strong van der Waals contacts and hydrogen bonds, implying that a conformational change must occur for the junction to branch-migrate or isomerize. At the branch point, two phosphate groups from one helix occupy the major groove of the other one, establishing sequence-specific hydrogen bonds. These interactions, together with different stacking energies and steric hindrances, explain the preference for a particular junction stacked conformer.
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The line below this paragraph, {{ABSTRACT_PUBMED_10504723}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10504723 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10504723}}
==About this Structure==
==About this Structure==
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[[Category: Four-way-junction]]
[[Category: Four-way-junction]]
[[Category: G:a mismatch]]
[[Category: G:a mismatch]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:19:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:23:55 2008''

Revision as of 10:23, 3 July 2008

Image:467d.png

Template:STRUCTURE 467d

The structure of a decamer forming a four-way junction

Template:ABSTRACT PUBMED 10504723

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a DNA Holliday junction., Ortiz-Lombardia M, Gonzalez A, Eritja R, Aymami J, Azorin F, Coll M, Nat Struct Biol. 1999 Oct;6(10):913-7. PMID:10504723

Page seeded by OCA on Thu Jul 3 13:23:55 2008

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