473d

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{{STRUCTURE_473d| PDB=473d | SCENE= }}
{{STRUCTURE_473d| PDB=473d | SCENE= }}
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'''NI2+/GUANINE INTERACTIONS AND NETROPSIN/GUANINE STACKING IN D(CGTATATACG)2'''
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===NI2+/GUANINE INTERACTIONS AND NETROPSIN/GUANINE STACKING IN D(CGTATATACG)2===
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==Overview==
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We present the structure of the decanucleotide d(CGTATATACG) determined by single crystal X-ray diffraction at 1.58 A resolution. A netropsin drug is found in the minor groove with guanine stacked on a pyrrole ring of the drug, a feature described here for the first time. The stacked guanine is an extra-helical base coming from the end of a neighbour oligonucleotide. This observation may open the way to the development of minor groove binding drugs with a higher sequence selectivity. The oligonucleotide is in the B-conformation, but the terminal base-pairs are disrupted: the cytosine residues are disordered while the guanine residues penetrate into the minor groove of neighbouring duplexes. Four hydrated Ni ions with octahedral co-ordination are found associated with the N7 atoms of each guanine. The high affinity of these ions with guanine suggests that they may be used as probes for specific guanine residues.
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The line below this paragraph, {{ABSTRACT_PUBMED_10610787}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10610787 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10610787}}
==About this Structure==
==About this Structure==
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[[Category: Netropsin/guanine stacking]]
[[Category: Netropsin/guanine stacking]]
[[Category: Ni2+/guanine interaction]]
[[Category: Ni2+/guanine interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:19:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:24:45 2008''

Revision as of 10:24, 3 July 2008

Image:473d.png

Template:STRUCTURE 473d

NI2+/GUANINE INTERACTIONS AND NETROPSIN/GUANINE STACKING IN D(CGTATATACG)2

Template:ABSTRACT PUBMED 10610787

About this Structure

Full crystallographic information is available from OCA.

Reference

Stacking interaction of guanine with netropsin in the minor groove of d(CGTATATACG)2., Abrescia NG, Malinina L, Subirana JA, J Mol Biol. 1999 Dec 3;294(3):657-66. PMID:10610787

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