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4cac

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[[Image:4cac.gif|left|200px]]
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{{Seed}}
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[[Image:4cac.png|left|200px]]
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{{STRUCTURE_4cac| PDB=4cac | SCENE= }}
{{STRUCTURE_4cac| PDB=4cac | SCENE= }}
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'''REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION'''
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===REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION===
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==Overview==
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The structure of human erythrocytic carbonic anhydrase II has been refined by constrained and restrained structure-factor least-squares refinement at 2.0 A resolution. The conventional crystallographic R value is 17.3%. Of 167 solvent molecules associated with the protein, four are buried and stabilize secondary structure elements. The zinc ion is ligated to three histidyl residues and one water molecule in a nearly tetrahedral geometry. In addition to the zinc-bound water, seven more water molecules are identified in the active site. Assuming that Glu-106 is deprotonated at pH 8.5, some of the hydrogen bond donor-acceptor relations in the active site can be assigned and are described here in detail. The O gamma 1 atom of Thr-199 donates its proton to the O epsilon 1 atom of Glu-106 and can function as a hydrogen bond acceptor only in additional hydrogen bonds.
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The line below this paragraph, {{ABSTRACT_PUBMED_3151019}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 3151019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3151019}}
==About this Structure==
==About this Structure==
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[[Category: Liljas, A.]]
[[Category: Liljas, A.]]
[[Category: Lindahl, M.]]
[[Category: Lindahl, M.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:21:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:30:53 2008''

Revision as of 10:30, 3 July 2008

Template:STRUCTURE 4cac

REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 3151019

About this Structure

4CAC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Refined structure of human carbonic anhydrase II at 2.0 A resolution., Eriksson AE, Jones TA, Liljas A, Proteins. 1988;4(4):274-82. PMID:3151019

Page seeded by OCA on Thu Jul 3 13:30:53 2008

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