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4gst

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[[Image:4gst.jpg|left|200px]]
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{{STRUCTURE_4gst| PDB=4gst | SCENE= }}
{{STRUCTURE_4gst| PDB=4gst | SCENE= }}
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'''REACTION COORDINATE MOTION IN AN SNAR REACTION CATALYZED BY GLUTATHIONE TRANSFERASE'''
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===REACTION COORDINATE MOTION IN AN SNAR REACTION CATALYZED BY GLUTATHIONE TRANSFERASE===
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==Overview==
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The three-dimensional structures of a class mu glutathione transferase in complex with a transition-state analogue, 1-(S-glutathionyl)-2,4,6-trinitrocyclohexadienate, and a product, 1-(S-glutathionyl)-2,4-dinitrobenzene, of a nucleophilic aromatic substitution (SNAr) reaction have been determined at 1.9- and 2.0-A resolution, respectively. The two structures represent snapshots along the reaction coordinate for the enzyme-catalyzed reaction of glutathione with 1-chloro-2,4-dinitrobenzene and reveal specific interactions between the enzyme, intermediate, and product that are important in catalysis. The geometries of the intermediate and product are used to postulate reaction coordinate motion during catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 8241147 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8241147}}
==About this Structure==
==About this Structure==
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[[Category: Ji, X.]]
[[Category: Ji, X.]]
[[Category: Glutathione transferase]]
[[Category: Glutathione transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:24:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:39:54 2008''

Revision as of 10:39, 3 July 2008

Image:4gst.png

Template:STRUCTURE 4gst

REACTION COORDINATE MOTION IN AN SNAR REACTION CATALYZED BY GLUTATHIONE TRANSFERASE

Template:ABSTRACT PUBMED 8241147

About this Structure

4GST is a Single protein structure of sequence from Rattus rattus. Full crystallographic information is available from OCA.

Reference

Snapshots along the reaction coordinate of an SNAr reaction catalyzed by glutathione transferase., Ji X, Armstrong RN, Gilliland GL, Biochemistry. 1993 Dec 7;32(48):12949-54. PMID:8241147

Page seeded by OCA on Thu Jul 3 13:39:54 2008

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