4i1b

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{{STRUCTURE_4i1b| PDB=4i1b | SCENE= }}
{{STRUCTURE_4i1b| PDB=4i1b | SCENE= }}
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'''FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE'''
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===FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE===
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==Overview==
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The molecular structure of interleukin-1 beta, a hormone-like cytokine with roles in several disease processes, has been determined at 2.0 A resolution and refined to a crystallographic R-factor of 0.19. The framework of this molecule consists of 12 antiparallel beta-strands exhibiting pseudo-3-fold symmetry. Six of the strands make up a beta-barrel with polar residues concentrated at either end. Analysis of the three-dimensional structure, together with results from site-directed mutagenesis and biochemical and immunological studies, suggest that the core of the beta-barrel plays an important functional role. A large patch of charged residues on one end of the barrel is proposed as the binding surface with which IL-1 interacts with its receptor.
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(as it appears on PubMed at http://www.pubmed.gov), where 1553379 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1553379}}
==About this Structure==
==About this Structure==
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[[Category: Veerapandian, B.]]
[[Category: Veerapandian, B.]]
[[Category: Cytokine]]
[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:25:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:41:37 2008''

Revision as of 10:41, 3 July 2008

Image:4i1b.png

Template:STRUCTURE 4i1b

FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE

Template:ABSTRACT PUBMED 1553379

About this Structure

4I1B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Functional implications of interleukin-1 beta based on the three-dimensional structure., Veerapandian B, Gilliland GL, Raag R, Svensson AL, Masui Y, Hirai Y, Poulos TL, Proteins. 1992 Jan;12(1):10-23. PMID:1553379

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