4tgf

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[[Image:4tgf.gif|left|200px]]
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[[Image:4tgf.png|left|200px]]
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{{STRUCTURE_4tgf| PDB=4tgf | SCENE= }}
{{STRUCTURE_4tgf| PDB=4tgf | SCENE= }}
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'''SOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DERIVED FROM 1*H NMR DATA'''
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===SOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DERIVED FROM 1*H NMR DATA===
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==Overview==
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The 600-MHz 1H NMR spectrum of the des-Val-Val mutant of human transforming growth factor alpha (TGF-alpha) was reassigned at pH = 6.3. The conformation space of des-Val-Val TGF-alpha was explored by distance geometry embedding followed by restrained molecular dynamics refinement using NOE distance constraints and some torsion angle constraints derived from J-couplings. Over 80 long-range NOE constraints were found by completely assigning all resolved cross-peaks in the NOESY spectra. Low NOE constraint violations were observed in structures obtained with the following three different refinement procedures: interactive annealing in DSPACE, AMBER 3.0 restrained molecular dynamics, and dynamic simulated annealing in XPLOR. The segment from Phe15 to Asp47 was found to be conformationally well-defined. Back-calculations of NOESY spectra were used to evaluate the quality of the structures. Our calculated structures resemble the ribbon diagram presentations that were recently reported by other groups. Several side-chain conformations appear to be well-defined as does the relative orientation of the C loop to the N-terminal half of the protein.
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The line below this paragraph, {{ABSTRACT_PUBMED_2261437}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 2261437 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2261437}}
==About this Structure==
==About this Structure==
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4TGF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TGF OCA].
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4TGF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TGF OCA].
==Reference==
==Reference==
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[[Category: Mueller, L.]]
[[Category: Mueller, L.]]
[[Category: Growth factor]]
[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:29:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:51:19 2008''

Revision as of 10:51, 3 July 2008

Image:4tgf.png

Template:STRUCTURE 4tgf

SOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DERIVED FROM 1*H NMR DATA

Template:ABSTRACT PUBMED 2261437

About this Structure

4TGF is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structures of human transforming growth factor alpha derived from 1H NMR data., Kline TP, Brown FK, Brown SC, Jeffs PW, Kopple KD, Mueller L, Biochemistry. 1990 Aug 28;29(34):7805-13. PMID:2261437

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