4ubp

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{{STRUCTURE_4ubp| PDB=4ubp | SCENE= }}
{{STRUCTURE_4ubp| PDB=4ubp | SCENE= }}
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'''STRUCTURE OF BACILLUS PASTEURII UREASE INHIBITED WITH ACETOHYDROXAMIC ACID AT 1.55 A RESOLUTION'''
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===STRUCTURE OF BACILLUS PASTEURII UREASE INHIBITED WITH ACETOHYDROXAMIC ACID AT 1.55 A RESOLUTION===
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==Overview==
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The structure of Bacillus pasteurii urease inhibited with acetohydroxamic acid was solved and refined anisotropically using synchrotron X-ray cryogenic diffraction data (1.55 A resolution, 99.5% completeness, data redundancy = 26, R-factor = 15.1%, PDB code 4UBP). The two Ni ions in the active site are separated by a distance of 3.53 A. The structure clearly shows the binding mode of the inhibitor anion, symmetrically bridging the two Ni ions in the active site through the hydroxamate oxygen and chelating one Ni ion through the carbonyl oxygen. The flexible flap flanking the active site cavity is in the open conformation. The possible implications of the results on structure-based molecular design of new urease inhibitors are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 10766443 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10766443}}
==About this Structure==
==About this Structure==
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[[Category: Nickel]]
[[Category: Nickel]]
[[Category: Urease]]
[[Category: Urease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:30:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:53:48 2008''

Revision as of 10:53, 3 July 2008

Image:4ubp.png

Template:STRUCTURE 4ubp

STRUCTURE OF BACILLUS PASTEURII UREASE INHIBITED WITH ACETOHYDROXAMIC ACID AT 1.55 A RESOLUTION

Template:ABSTRACT PUBMED 10766443

About this Structure

4UBP is a Protein complex structure of sequences from Sporosarcina pasteurii. Full crystallographic information is available from OCA.

Reference

The complex of Bacillus pasteurii urease with acetohydroxamate anion from X-ray data at 1.55 A resolution., Benini S, Rypniewski WR, Wilson KS, Miletti S, Ciurli S, Mangani S, J Biol Inorg Chem. 2000 Feb;5(1):110-8. PMID:10766443

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