5bna

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{{STRUCTURE_5bna| PDB=5bna | SCENE= }}
{{STRUCTURE_5bna| PDB=5bna | SCENE= }}
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'''THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G'''
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===THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G===
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==Overview==
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When cisplatin [cis- diamminodichloroplatinum (II)] is diffused into pre-grown crystals of the B-DNA double-helical dodecamer C-G-C-G-A-A-T-T-C-G-C-G, it binds preferentially to the N7 positions of guanines, with what probably is an aquo bridge between Pt and the adjacent O6 atom of the same guanine. The entire guanine ring moves slightly toward the platinum site, into the major groove. Only three of the eight potential cisplatin binding sites on guanines actually are occupied, and this differential reactivity can be explained in terms of the relative freedom of motion of guanines toward the major groove. This shift of guanines upon ligation may weaken the glycosyl bond and assist in the depurination that leads to mismatch SOS repair and G.C. to T.A. transversion.
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(as it appears on PubMed at http://www.pubmed.gov), where 6539674 is the PubMed ID number.
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{{ABSTRACT_PUBMED_6539674}}
==About this Structure==
==About this Structure==
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[[Category: Double helix]]
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[[Category: Modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:32:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:57:17 2008''

Revision as of 10:57, 3 July 2008

Image:5bna.png

Template:STRUCTURE 5bna

THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G

Template:ABSTRACT PUBMED 6539674

About this Structure

Full crystallographic information is available from OCA.

Reference

The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G., Wing RM, Pjura P, Drew HR, Dickerson RE, EMBO J. 1984 May;3(5):1201-6. PMID:6539674

Page seeded by OCA on Thu Jul 3 13:57:17 2008

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