5eas

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{{STRUCTURE_5eas| PDB=5eas | SCENE= }}
{{STRUCTURE_5eas| PDB=5eas | SCENE= }}
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'''5-EPI-ARISTOLOCHENE SYNTHASE FROM NICOTIANA TABACUM'''
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===5-EPI-ARISTOLOCHENE SYNTHASE FROM NICOTIANA TABACUM===
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==Overview==
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Terpene cyclases catalyze the synthesis of cyclic terpenes with 10-, 15-, and 20-carbon acyclic isoprenoid diphosphates as substrates. Plants have been a source of these natural products by providing a homologous set of terpene synthases. The crystal structures of 5-epi-aristolochene synthase, a sesquiterpene cyclase from tobacco, alone and complexed separately with two farnesyl diphosphate analogs were analyzed. These structures reveal an unexpected enzymatic mechanism for the synthesis of the bicyclic product, 5-epi-aristolochene, and provide a basis for understanding the stereochemical selectivity displayed by other cyclases in the biosynthesis of pharmacologically important cyclic terpenes. As such, these structures provide templates for the engineering of novel terpene cyclases.
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==About this Structure==
==About this Structure==
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[[Category: Isoprenoid synthase]]
[[Category: Isoprenoid synthase]]
[[Category: Natural products biosynthesis]]
[[Category: Natural products biosynthesis]]
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Revision as of 11:00, 3 July 2008

Image:5eas.png

Template:STRUCTURE 5eas

5-EPI-ARISTOLOCHENE SYNTHASE FROM NICOTIANA TABACUM

Template:ABSTRACT PUBMED 9295271

About this Structure

5EAS is a Single protein structure of sequence from Nicotiana tabacum. Full crystallographic information is available from OCA.

Reference

Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase., Starks CM, Back K, Chappell J, Noel JP, Science. 1997 Sep 19;277(5333):1815-20. PMID:9295271

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