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5ttr

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{{STRUCTURE_5ttr| PDB=5ttr | SCENE= }}
{{STRUCTURE_5ttr| PDB=5ttr | SCENE= }}
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'''LEU 55 PRO TRANSTHYRETIN CRYSTAL STRUCTURE'''
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===LEU 55 PRO TRANSTHYRETIN CRYSTAL STRUCTURE===
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==Overview==
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The x-ray crystal structure of the amyloidogenic Leu55 --&gt; Pro transthyretin (TTR) variant, implicated as the causative agent in early-onset familial amyloidotic polyneuropathy (Jacobson, D. R., McFarlin, D. E., Kane, I., and Buxbaum, J. N. (1992) Hum. Genet. 89, 353-356), has been solved by molecular replacement, refined at 2.7 A to a Rcryst value of 0.190 (Fobs &gt; 2.0sigma), and compared with wild-type transthyretin to understand the molecular mechanism(s) involved in amyloidogenesis. Leu55 --&gt; Pro TTR crystallizes in space group C2, with eight monomers in the asymmetric unit, and the observed packing contacts are considerably different from those described for the wild-type protein. Refinement of the crystal structure shows that the proline for leucine substitution disrupts the hydrogen bonds between strands D and A, resulting in different interface contacts. Based on the assumption that the observed packing contacts may be significant for amyloidogenesis, a model for the TTR amyloid is proposed. It consists of a tubular structure with inner and outer diameters approximately of 30 and 100 A and four monomers per cross-section.
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(as it appears on PubMed at http://www.pubmed.gov), where 9733771 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9733771}}
==About this Structure==
==About this Structure==
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[[Category: Transport]]
[[Category: Transport]]
[[Category: Transthyretin]]
[[Category: Transthyretin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:38:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:12:32 2008''

Revision as of 11:12, 3 July 2008

Image:5ttr.png

Template:STRUCTURE 5ttr

LEU 55 PRO TRANSTHYRETIN CRYSTAL STRUCTURE

Template:ABSTRACT PUBMED 9733771

About this Structure

5TTR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of amyloidogenic Leu55 --> Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils., Sebastiao MP, Saraiva MJ, Damas AM, J Biol Chem. 1998 Sep 18;273(38):24715-22. PMID:9733771

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