6cmh

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[[Image:6cmh.gif|left|200px]]
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{{Seed}}
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[[Image:6cmh.png|left|200px]]
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{{STRUCTURE_6cmh| PDB=6cmh | SCENE= }}
{{STRUCTURE_6cmh| PDB=6cmh | SCENE= }}
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'''SYNTHETIC LINEAR MODIFIED ENDOTHELIN-1 AGONIST'''
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===SYNTHETIC LINEAR MODIFIED ENDOTHELIN-1 AGONIST===
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==Overview==
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The solution structure of a biologically active modified linear endothelin-1 analogue, ET1-21[Cys(Acm)1,15, Aib3,11, Leu7], has been determined for the first time by two-dimensional nuclear magnetic resonance spectroscopy in a methanol-d3/water solvent mixture. Out of approximately one hundred linear peptide analogues tested by biological assay, this peptide, together with a dozen others, showed significant ETB selective agonist activity. Here we report the solution structure of an ETB selective agonist of a full-length, synthetic linear endothelin analogue. The calculated structures indicate that the peptide adopts an alpha-helical conformation between residues Ser5-His16, whilst both N- and C-termini show no preferred conformation. These results suggest that the disulphide bridges normally associated with endothelin and sarafotoxin peptides may not necessarily be important for either ETB receptor binding activity or the formation of a helical conformation in solution.
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(as it appears on PubMed at http://www.pubmed.gov), where 10231710 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10231710}}
==About this Structure==
==About this Structure==
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6CMH is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CMH OCA].
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6CMH is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CMH OCA].
==Reference==
==Reference==
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[[Category: Endothelin-1]]
[[Category: Endothelin-1]]
[[Category: Vasoconstrictor]]
[[Category: Vasoconstrictor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:39:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:16:12 2008''

Revision as of 11:16, 3 July 2008

Image:6cmh.png

Template:STRUCTURE 6cmh

SYNTHETIC LINEAR MODIFIED ENDOTHELIN-1 AGONIST

Template:ABSTRACT PUBMED 10231710

About this Structure

6CMH is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling., Hewage CM, Jiang L, Parkinson JA, Ramage R, Sadler IH, J Pept Res. 1999 Mar;53(3):223-33. PMID:10231710

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