6tmn

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[[Image:6tmn.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_6tmn| PDB=6tmn | SCENE= }}
{{STRUCTURE_6tmn| PDB=6tmn | SCENE= }}
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'''STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND'''
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===STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND===
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==Overview==
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The mode of binding to thermolysin of the ester analog Cbz-GlyP-(O)-Leu-Leu has been determined by x-ray crystallography and shown to be virtually identical (maximum difference 0.2 angstrom) with the corresponding peptide analog Cbz-GlyP-(NH)-Leu-Leu. The two inhibitors provide a matched pair of enzyme-inhibitor complexes that differ by 4.1 kilocalories per mole in intrinsic binding energy but are essentially identical except for the presence or absence of a specific hydrogen bond.
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(as it appears on PubMed at http://www.pubmed.gov), where 3810156 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3810156}}
==About this Structure==
==About this Structure==
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[[Category: Matthews, B W.]]
[[Category: Matthews, B W.]]
[[Category: Tronrud, D E.]]
[[Category: Tronrud, D E.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:43:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:26:54 2008''

Revision as of 11:26, 3 July 2008

Image:6tmn.png

Template:STRUCTURE 6tmn

STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND

Template:ABSTRACT PUBMED 3810156

About this Structure

6TMN is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:3810156

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