7fab

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{{STRUCTURE_7fab| PDB=7fab | SCENE= }}
{{STRUCTURE_7fab| PDB=7fab | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN IMMUNOGLOBULIN FRAGMENT FAB NEW REFINED AT 2.0 ANGSTROMS RESOLUTION'''
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===CRYSTAL STRUCTURE OF HUMAN IMMUNOGLOBULIN FRAGMENT FAB NEW REFINED AT 2.0 ANGSTROMS RESOLUTION===
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==Overview==
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The three-dimensional structure of the human immunoglobulin fragment Fab New (IgG1, lambda) has been refined to a crystallographic R-factor of 16.9% to 2 A resolution. Rms deviations of the final model from ideal geometry are 0.014 A for bond distances and 3.03 degrees for bond angles. Refinement was based on a new X-ray data set including 28,301 reflections with F &gt; 2.5 sigma(F) from 6.0 to 2.0 A resolution. The starting model for the refinement procedure reported here is from the Brookhaven Protein Data Bank entry 3FAB (rev. 1981). Differences between the initial and final models include modified polypeptide-chain folding in the third complementarity-determining region (CDR3) and the third framework region (FR3) of VH and in some exposed loops of CL and CH1. Amino acid sequence changes were determined at a number of positions by inspection of difference electron density maps. The incorporation of amino acid sequence changes results in an improved VH framework model for the "humanization" of monoclonal antibodies.
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The line below this paragraph, {{ABSTRACT_PUBMED_1438175}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1438175 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1438175}}
==About this Structure==
==About this Structure==
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[[Category: Saul, F.]]
[[Category: Saul, F.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:44:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:32:38 2008''

Revision as of 11:32, 3 July 2008

Image:7fab.png

Template:STRUCTURE 7fab

CRYSTAL STRUCTURE OF HUMAN IMMUNOGLOBULIN FRAGMENT FAB NEW REFINED AT 2.0 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 1438175

About this Structure

7FAB is a Protein complex structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entries and 1fab. Full crystallographic information is available from OCA.

Reference

Crystal structure of human immunoglobulin fragment Fab New refined at 2.0 A resolution., Saul FA, Poljak RJ, Proteins. 1992 Nov;14(3):363-71. PMID:1438175

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