2v1u

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[[Image:2v1u.gif|left|200px]]
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{{Seed}}
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[[Image:2v1u.png|left|200px]]
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{{STRUCTURE_2v1u| PDB=2v1u | SCENE= }}
{{STRUCTURE_2v1u| PDB=2v1u | SCENE= }}
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'''STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA'''
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===STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA===
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==Overview==
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DNA replication in archaea and in eukaryotes share many similarities. We report the structure of an archaeal origin recognition complex protein, ORC1, bound to an origin recognition box, a DNA sequence that is found in multiple copies at replication origins. DNA binding is mediated principally by a C-terminal winged helix domain that inserts deeply into the major and minor grooves, widening them both. However, additional DNA contacts are made with the N-terminal AAA+ domain, which inserts into the minor groove at a characteristic G-rich sequence, inducing a 35 degrees bend in the duplex and providing directionality to the binding site. Both contact regions also induce substantial unwinding of the DNA. The structure provides insight into the initial step in assembly of a replication origin and recruitment of minichromosome maintenance (MCM) helicase to that origin.
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(as it appears on PubMed at http://www.pubmed.gov), where 17761880 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17761880}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Replication]]
[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:03:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Jul 5 10:52:43 2008''

Revision as of 07:52, 5 July 2008

Image:2v1u.png

Template:STRUCTURE 2v1u

STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA

Template:ABSTRACT PUBMED 17761880

About this Structure

2V1U is a Protein complex structure of sequences from Aeropyrum pernix. Full crystallographic information is available from OCA.

Reference

Structural basis of DNA replication origin recognition by an ORC protein., Gaudier M, Schuwirth BS, Westcott SL, Wigley DB, Science. 2007 Aug 31;317(5842):1213-6. PMID:17761880

Page seeded by OCA on Sat Jul 5 10:52:43 2008

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