1s3r

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[[Image:1s3r.gif|left|200px]]
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{{Seed}}
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[[Image:1s3r.png|left|200px]]
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{{STRUCTURE_1s3r| PDB=1s3r | SCENE= }}
{{STRUCTURE_1s3r| PDB=1s3r | SCENE= }}
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'''Crystal structure of the human-specific toxin intermedilysin'''
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===Crystal structure of the human-specific toxin intermedilysin===
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==Overview==
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The cholesterol-dependent cytolysins (CDCs), a superfamily of pore-forming toxins, are characterized by a conserved undecapeptide motif that is believed to be critical for membrane recognition by means of cholesterol. Intermedilysin (ILY), an unusual member of the CDCs, exhibits specificity for human cells and contains nonconservative substitutions in the motif. We show that the cellular specificity of ILY is based on its ability to specifically bind to human cells and does not involve some other feature of the CDC mechanism. Furthermore, cellular recognition by ILY appears to be encoded in domain 4 alone but does not involve the variant undecapeptide of ILY. We show that the undecapeptide is involved in the prepore-to-pore conversion of ILY and so demonstrate a direct connection between the structure of the undecapeptide and the prepore-to-pore transition. We have determined the crystal structure of ILY, which, when compared to the known structure of a prototypical CDC, suggests that the basic aspects of its 3D structure are likely to be conserved in all CDCs.
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The line below this paragraph, {{ABSTRACT_PUBMED_15637162}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15637162 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15637162}}
==About this Structure==
==About this Structure==
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[[Category: Tweten, R K.]]
[[Category: Tweten, R K.]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:15:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Jul 5 16:19:36 2008''

Revision as of 13:19, 5 July 2008

Image:1s3r.png

Template:STRUCTURE 1s3r

Crystal structure of the human-specific toxin intermedilysin

Template:ABSTRACT PUBMED 15637162

About this Structure

1S3R is a Single protein structure of sequence from Streptococcus intermedius. Full crystallographic information is available from OCA.

Reference

Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin., Polekhina G, Giddings KS, Tweten RK, Parker MW, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):600-5. Epub 2005 Jan 6. PMID:15637162

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