3ana

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{{STRUCTURE_3ana| PDB=3ana | SCENE= }}
{{STRUCTURE_3ana| PDB=3ana | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF D(GGGATCCC) IN THE CRYSTALLINE STATE'''
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===THREE-DIMENSIONAL STRUCTURE OF D(GGGATCCC) IN THE CRYSTALLINE STATE===
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==Overview==
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The structure of the self-complementary octamer d(GGGATCCC) has been analysed by single crystal X-ray diffraction methods at a nominal resolution of 2.5 A. With acceptable stereochemistry of the model the crystallographic R factor was 16.6% after restrained least-squares refinement. In the crystal, d(GGGATCCC) forms an A-DNA double helix with slightly varying conformation of the two strands. The average displacement of the base pairs from the helix axis is unusually large and is accompanied by pronounced sliding of the base pairs along their long axes at all dinucleotide steps except for the central AT. With 12 base pairs per complete turn the helix is considerably underwound. As observed with most oligodeoxyribonucleotides analysed by X-ray crystallography so far, the octamer displays reduced base pair tilt, increased rise per base pair and a more open major groove compared with canonical A-DNA. We propose that, based on these parameters, three A-helical sub-families may be defined; d(GGGATCCC) then is a representative of the class with intermediate tilt, rise, and major groove width.
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(as it appears on PubMed at http://www.pubmed.gov), where 3166518 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3166518}}
==About this Structure==
==About this Structure==
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[[Category: A-dna]]
[[Category: A-dna]]
[[Category: Double helix]]
[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:19:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 6 00:59:29 2008''

Revision as of 21:59, 5 July 2008

Image:3ana.png

Template:STRUCTURE 3ana

THREE-DIMENSIONAL STRUCTURE OF D(GGGATCCC) IN THE CRYSTALLINE STATE

Template:ABSTRACT PUBMED 3166518

About this Structure

Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of d(GGGATCCC) in the crystalline state., Lauble H, Frank R, Blocker H, Heinemann U, Nucleic Acids Res. 1988 Aug 25;16(16):7799-816. PMID:3166518

Page seeded by OCA on Sun Jul 6 00:59:29 2008

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