2eyw

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[[Image:2eyw.jpg|left|200px]]
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{{Seed}}
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[[Image:2eyw.png|left|200px]]
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{{STRUCTURE_2eyw| PDB=2eyw | SCENE= }}
{{STRUCTURE_2eyw| PDB=2eyw | SCENE= }}
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'''N-terminal SH3 domain of CT10-Regulated Kinase'''
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===N-terminal SH3 domain of CT10-Regulated Kinase===
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==Overview==
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CRKI (SH2-SH3) and CRKII (SH2-SH3-SH3) are splicing isoforms of the oncoprotein CRK that regulate transcription and cytoskeletal reorganization for cell growth and motility by linking tyrosine kinases to small G proteins. CRKI shows substantial transforming activity, whereas the activity of CRKII is low, and phosphorylated CRKII has no biological activity whatsoever. The molecular mechanisms underlying the distinct biological activities of the CRK proteins remain elusive. We determined the solution structures of CRKI, CRKII and phosphorylated CRKII by NMR and identified the molecular mechanism that gives rise to their activities. Results from mutational analysis using rodent 3Y1 fibroblasts were consistent with those from the structural studies. Together, these data suggest that the linker region modulates the binding of CRKII to its targets, thus regulating cell growth and motility.
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The line below this paragraph, {{ABSTRACT_PUBMED_17515907}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17515907 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17515907}}
==About this Structure==
==About this Structure==
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2EYW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYW OCA].
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2EYW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYW OCA].
==Reference==
==Reference==
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[[Category: Tanaka, S.]]
[[Category: Tanaka, S.]]
[[Category: Sh3]]
[[Category: Sh3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:16:09 2008''
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 9 10:04:04 2008''

Revision as of 07:04, 9 July 2008

Image:2eyw.png

Template:STRUCTURE 2eyw

N-terminal SH3 domain of CT10-Regulated Kinase

Template:ABSTRACT PUBMED 17515907

About this Structure

2EYW is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK., Kobashigawa Y, Sakai M, Naito M, Yokochi M, Kumeta H, Makino Y, Ogura K, Tanaka S, Inagaki F, Nat Struct Mol Biol. 2007 Jun;14(6):503-10. Epub 2007 May 21. PMID:17515907

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