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2qc1

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{{STRUCTURE_2qc1| PDB=2qc1 | SCENE= }}
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'''Crystal structure of the extracellular domain of the nicotinic acetylcholine receptor 1 subunit bound to alpha-bungarotoxin at 1.9 A resolution'''
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===Crystal structure of the extracellular domain of the nicotinic acetylcholine receptor 1 subunit bound to alpha-bungarotoxin at 1.9 A resolution===
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==Overview==
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We determined the crystal structure of the extracellular domain of the mouse nicotinic acetylcholine receptor (nAChR) alpha1 subunit bound to alpha-bungarotoxin at 1.94 A resolution. This structure is the first atomic-resolution view of a nAChR subunit extracellular domain, revealing receptor-specific features such as the main immunogenic region (MIR), the signature Cys-loop and the N-linked carbohydrate chain. The toxin binds to the receptor through extensive protein-protein and protein-sugar interactions. To our surprise, the structure showed a well-ordered water molecule and two hydrophilic residues deep in the core of the alpha1 subunit. The two hydrophilic core residues are highly conserved in nAChRs, but correspond to hydrophobic residues in the nonchannel homolog acetylcholine-binding proteins. We carried out site-directed mutagenesis and electrophysiology analyses to assess the functional role of the glycosylation and the hydrophilic core residues. Our structural and functional studies show essential features of the nAChR and provide new insights into the gating mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 17643119 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17643119}}
==About this Structure==
==About this Structure==
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[[Category: Nicotinic acetylcholine receptor]]
[[Category: Nicotinic acetylcholine receptor]]
[[Category: Protein binding]]
[[Category: Protein binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:42:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 9 10:06:50 2008''

Revision as of 07:06, 9 July 2008

Image:2qc1.png

Template:STRUCTURE 2qc1

Crystal structure of the extracellular domain of the nicotinic acetylcholine receptor 1 subunit bound to alpha-bungarotoxin at 1.9 A resolution

Template:ABSTRACT PUBMED 17643119

About this Structure

2QC1 is a Protein complex structure of sequences from Bungarus multicinctus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution., Dellisanti CD, Yao Y, Stroud JC, Wang ZZ, Chen L, Nat Neurosci. 2007 Aug;10(8):953-62. Epub 2007 Jul 22. PMID:17643119

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