This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2q41

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2q41.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2q41.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2q41| PDB=2q41 | SCENE= }}
{{STRUCTURE_2q41| PDB=2q41 | SCENE= }}
-
'''Ensemble refinement of the protein crystal structure of spermidine synthase from Arabidopsis thaliana gene At1g23820'''
+
===Ensemble refinement of the protein crystal structure of spermidine synthase from Arabidopsis thaliana gene At1g23820===
-
==Overview==
+
<!--
-
X-ray crystallography typically uses a single set of coordinates and B factors to describe macromolecular conformations. Refinement of multiple copies of the entire structure has been previously used in specific cases as an alternative means of representing structural flexibility. Here, we systematically validate this method by using simulated diffraction data, and we find that ensemble refinement produces better representations of the distributions of atomic positions in the simulated structures than single-conformer refinements. Comparison of principal components calculated from the refined ensembles and simulations shows that concerted motions are captured locally, but that correlations dissipate over long distances. Ensemble refinement is also used on 50 experimental structures of varying resolution and leads to decreases in R(free) values, implying that improvements in the representation of flexibility observed for the simulated structures may apply to real structures. These gains are essentially independent of resolution or data-to-parameter ratio, suggesting that even structures at moderate resolution can benefit from ensemble refinement.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17850744}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17850744 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17850744}}
==About this Structure==
==About this Structure==
Line 40: Line 44:
[[Category: Spermidine synthase]]
[[Category: Spermidine synthase]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:17:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:32:44 2008''

Revision as of 09:32, 10 July 2008

Image:2q41.png

Template:STRUCTURE 2q41

Ensemble refinement of the protein crystal structure of spermidine synthase from Arabidopsis thaliana gene At1g23820

Template:ABSTRACT PUBMED 17850744

About this Structure

2Q41 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Ensemble refinement of protein crystal structures: validation and application., Levin EJ, Kondrashov DA, Wesenberg GE, Phillips GN Jr, Structure. 2007 Sep;15(9):1040-52. PMID:17850744

Page seeded by OCA on Thu Jul 10 12:32:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2q41"
Personal tools