1o0a

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{{STRUCTURE_1o0a| PDB=1o0a | SCENE= }}
{{STRUCTURE_1o0a| PDB=1o0a | SCENE= }}
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'''BACTERIORHODOPSIN L INTERMEDIATE AT 1.62 A RESOLUTION'''
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===BACTERIORHODOPSIN L INTERMEDIATE AT 1.62 A RESOLUTION===
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==Overview==
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We produced the L intermediate of the photocycle in a bacteriorhodopsin crystal in photo-stationary state at 170 K with red laser illumination at 60% occupancy, and determined its structure to 1.62 A resolution. With this model, high-resolution structural information is available for the initial bacteriorhodopsin, as well as the first five states in the transport cycle. These states involve photo-isomerization of the retinal and its initial configurational changes, deprotonation of the retinal Schiff base and the coupled release of a proton to the extracellular membrane surface, and the switch event that allows reprotonation of the Schiff base from the cytoplasmic side. The six structural models describe the transformations of the retinal and its interaction with water 402, Asp85, and Asp212 in atomic detail, as well as the displacements of functional residues farther from the Schiff base. The changes provide rationales for how relaxation of the distorted retinal causes movements of water and protein atoms that result in vectorial proton transfers to and from the Schiff base.
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{{ABSTRACT_PUBMED_12691752}}
==About this Structure==
==About this Structure==
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[[Category: Retinal protein]]
[[Category: Retinal protein]]
[[Category: Serpentine]]
[[Category: Serpentine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:12:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:37:18 2008''

Revision as of 09:37, 10 July 2008

Image:1o0a.png

Template:STRUCTURE 1o0a

BACTERIORHODOPSIN L INTERMEDIATE AT 1.62 A RESOLUTION

Template:ABSTRACT PUBMED 12691752

About this Structure

1O0A is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.

Reference

Mechanism of proton transport in bacteriorhodopsin from crystallographic structures of the K, L, M1, M2, and M2' intermediates of the photocycle., Lanyi JK, Schobert B, J Mol Biol. 2003 Apr 25;328(2):439-50. PMID:12691752

Page seeded by OCA on Thu Jul 10 12:37:18 2008

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