1qba

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{{STRUCTURE_1qba| PDB=1qba | SCENE= }}
{{STRUCTURE_1qba| PDB=1qba | SCENE= }}
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'''BACTERIAL CHITOBIASE, GLYCOSYL HYDROLASE FAMILY 20'''
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===BACTERIAL CHITOBIASE, GLYCOSYL HYDROLASE FAMILY 20===
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==Overview==
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Chitin, the second most abundant polysaccharide on earth, is degraded by chitinases and chitobiases. The structure of Serratia marcescens chitobiase has been refined at 1.9 A resolution. The mature protein is folded into four domains and its active site is situated at the C-terminal end of the central (beta alpha)8-barrel. Based on the structure of the complex with the substrate disaccharide chitobiose, we propose an acid-base reaction mechanism, in which only one protein carboxylate acts as catalytic acid, while the nucleophile is the polar acetamido group of the sugar in a substrate-assisted reaction. The structural data lead to the hypothesis that the reaction proceeds with retention of anomeric configuration. The structure allows us to model the catalytic domain of the homologous hexosaminidases to give a structural rationale to pathogenic mutations that underlie Tay-Sachs and Sandhoff disease.
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(as it appears on PubMed at http://www.pubmed.gov), where 8673609 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8673609}}
==About this Structure==
==About this Structure==
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[[Category: Chitobiase]]
[[Category: Chitobiase]]
[[Category: Glycosyl hydrolase]]
[[Category: Glycosyl hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:05:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:52:08 2008''

Revision as of 09:52, 10 July 2008

Image:1qba.png

Template:STRUCTURE 1qba

BACTERIAL CHITOBIASE, GLYCOSYL HYDROLASE FAMILY 20

Template:ABSTRACT PUBMED 8673609

About this Structure

1QBA is a Single protein structure of sequence from Serratia marcescens. Full crystallographic information is available from OCA.

Reference

Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease., Tews I, Perrakis A, Oppenheim A, Dauter Z, Wilson KS, Vorgias CE, Nat Struct Biol. 1996 Jul;3(7):638-48. PMID:8673609

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