1u9a

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{{STRUCTURE_1u9a| PDB=1u9a | SCENE= }}
{{STRUCTURE_1u9a| PDB=1u9a | SCENE= }}
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'''HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9'''
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===HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9===
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==Overview==
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Murine/human ubiquitin-conjugating enzyme Ubc9 is a functional homolog of Saccharomyces cerevisiae Ubc9 that is essential for the viability of yeast cells with a specific role in the G2-M transition of the cell cycle. The structure of recombinant mammalian Ubc9 has been determined from two crystal forms at 2.0 A resolution. Like Arabidopsis thaliana Ubc1 and S. cerevisiae Ubc4, murine/human Ubc9 was crystallized as a monomer, suggesting that previously reported hetero- and homo-interactions among Ubcs may be relatively weak or indirect. Compared with the known crystal structures of Ubc1 and Ubc4, which regulate different cellular processes, Ubc9 has a 5-residue insertion that forms a very exposed tight beta-hairpin and a 2-residue insertion that forms a bulge in a loop close to the active site. Mammalian Ubc9 also possesses a distinct electrostatic potential distribution that may provide possible clues to its remarkable ability to interact with other proteins. The 2-residue insertion and other sequence and structural heterogeneity observed at the catalytic site suggest that different Ubcs may utilize catalytic mechanisms of varying efficiency and substrate specificity.
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{{ABSTRACT_PUBMED_9261152}}
==About this Structure==
==About this Structure==
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[[Category: Ubiquitin-conjugating enzyme]]
[[Category: Ubiquitin-conjugating enzyme]]
[[Category: Ubiquitin-directed proteolysis]]
[[Category: Ubiquitin-directed proteolysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:52:14 2008''

Revision as of 09:52, 10 July 2008

Image:1u9a.png

Template:STRUCTURE 1u9a

HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9

Template:ABSTRACT PUBMED 9261152

About this Structure

1U9A is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system., Tong H, Hateboer G, Perrakis A, Bernards R, Sixma TK, J Biol Chem. 1997 Aug 22;272(34):21381-7. PMID:9261152

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