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8ohm

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{{STRUCTURE_8ohm| PDB=8ohm | SCENE= }}
{{STRUCTURE_8ohm| PDB=8ohm | SCENE= }}
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'''CRYSTAL STRUCTURE OF RNA HELICASE FROM GENOTYPE 1B HEPATITIS C VIRUS: MECHANISM OF UNWINDING DUPLEX RNA'''
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===CRYSTAL STRUCTURE OF RNA HELICASE FROM GENOTYPE 1B HEPATITIS C VIRUS: MECHANISM OF UNWINDING DUPLEX RNA===
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==Overview==
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Crystal structure of RNA helicase domain from genotype 1b hepatitis C virus has been determined at 2.3 A resolution by the multiple isomorphous replacement method. The structure consists of three domains that form a Y-shaped molecule. One is a NTPase domain containing two highly conserved NTP binding motifs. Another is an RNA binding domain containing a conserved RNA binding motif. The third is a helical domain that contains no beta-strand. The RNA binding domain of the molecule is distinctively separated from the other two domains forming an interdomain cleft into which single stranded RNA can be modeled. A channel is found between a pair of symmetry-related molecules which exhibit the most extensive crystal packing interactions. A stretch of single stranded RNA can be modeled with electrostatic complementarity into the interdomain cleft and continuously through the channel. These observations suggest that some form of this dimer is likely to be the functional form that unwinds double stranded RNA processively by passing one strand of RNA through the channel and passing the other strand outside of the dimer. A "descending molecular see-saw" model is proposed that is consistent with directionality of unwinding and other physicochemical properties of RNA helicases.
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(as it appears on PubMed at http://www.pubmed.gov), where 9614113 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9614113}}
==About this Structure==
==About this Structure==
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[[Category: Rna helicase]]
[[Category: Rna helicase]]
[[Category: Unwinding mechanism]]
[[Category: Unwinding mechanism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:51:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:55:18 2008''

Revision as of 09:55, 11 July 2008

Image:8ohm.png

Template:STRUCTURE 8ohm

CRYSTAL STRUCTURE OF RNA HELICASE FROM GENOTYPE 1B HEPATITIS C VIRUS: MECHANISM OF UNWINDING DUPLEX RNA

Template:ABSTRACT PUBMED 9614113

About this Structure

8OHM is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of RNA helicase from genotype 1b hepatitis C virus. A feasible mechanism of unwinding duplex RNA., Cho HS, Ha NC, Kang LW, Chung KM, Back SH, Jang SK, Oh BH, J Biol Chem. 1998 Jun 12;273(24):15045-52. PMID:9614113

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