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9hvp

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[[Image:9hvp.gif|left|200px]]
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{{STRUCTURE_9hvp| PDB=9hvp | SCENE= }}
{{STRUCTURE_9hvp| PDB=9hvp | SCENE= }}
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'''DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE'''
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===DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE===
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==Overview==
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A two-fold (C2) symmetric inhibitor of the protease of human immunodeficiency virus type-1 (HIV-1) has been designed on the basis of the three-dimensional symmetry of the enzyme active site. The symmetric molecule inhibited both protease activity and acute HIV-1 infection in vitro, was at least 10,000-fold more potent against HIV-1 protease than against related enzymes, and appeared to be stable to degradative enzymes. The 2.8 angstrom crystal structure of the inhibitor-enzyme complex demonstrated that the inhibitor binds to the enzyme in a highly symmetric fashion.
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(as it appears on PubMed at http://www.pubmed.gov), where 2200122 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2200122}}
==About this Structure==
==About this Structure==
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[[Category: Erickson, J.]]
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[[Category: Neidhart, D J.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:53:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:55:46 2008''

Revision as of 09:55, 11 July 2008

Image:9hvp.png

Template:STRUCTURE 9hvp

DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE

Template:ABSTRACT PUBMED 2200122

About this Structure

9HVP is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease., Erickson J, Neidhart DJ, VanDrie J, Kempf DJ, Wang XC, Norbeck DW, Plattner JJ, Rittenhouse JW, Turon M, Wideburg N, et al., Science. 1990 Aug 3;249(4968):527-33. PMID:2200122

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