8mht

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[[Image:8mht.gif|left|200px]]
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{{Seed}}
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[[Image:8mht.png|left|200px]]
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{{STRUCTURE_8mht| PDB=8mht | SCENE= }}
{{STRUCTURE_8mht| PDB=8mht | SCENE= }}
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'''CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX'''
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===CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX===
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==Overview==
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Three structures have been determined for complexes between HhaI methyltransferase (M.HhaI) and oligonucleotides containing a G:A, G:U or G:AP (AP = abasic or apurinic/apyrimidinic) mismatch at the target base pair. The mismatched adenine, uracil and abasic site are all flipped out of the DNA helix and located in the enzyme's active-site pocket, adopting the same conformation as in the flipped-out normal substrate. These results, particularly the flipped-out abasic deoxyribose sugar, provide insight into the mechanism of base flipping. If the process involves the protein pushing the base out of the helix, then the push must take place not on the base, but rather on the sugar-phosphate backbone. Thus rotation of the DNA backbone is probably the key to base flipping.
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(as it appears on PubMed at http://www.pubmed.gov), where 9783745 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9783745}}
==About this Structure==
==About this Structure==
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[[Category: Restriction system]]
[[Category: Restriction system]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:51:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:59:34 2008''

Revision as of 09:59, 11 July 2008

Image:8mht.png

Template:STRUCTURE 8mht

CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX

Template:ABSTRACT PUBMED 9783745

About this Structure

8MHT is a Single protein structure of sequence from Haemophilus haemolyticus. Full crystallographic information is available from OCA.

Reference

Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base., O'Gara M, Horton JR, Roberts RJ, Cheng X, Nat Struct Biol. 1998 Oct;5(10):872-7. PMID:9783745

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