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3b8k

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{{STRUCTURE_3b8k| PDB=3b8k | SCENE= }}
{{STRUCTURE_3b8k| PDB=3b8k | SCENE= }}
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'''Structure of the Truncated Human Dihydrolipoyl Acetyltransferase (E2)'''
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===Structure of the Truncated Human Dihydrolipoyl Acetyltransferase (E2)===
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==Overview==
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Dihydrolipoyl acetyltransferase (E2) is the central component of pyruvate dehydrogenase complex (PDC), which converts pyruvate to acetyl-CoA. Structural comparison by cryo-electron microscopy (cryo-EM) of the human full-length and truncated E2 (tE2) cores revealed flexible linkers emanating from the edges of trimers of the internal catalytic domains. Using the secondary structure constraints revealed in our 8 A cryo-EM reconstruction and the prokaryotic tE2 atomic structure as a template, we derived a pseudo atomic model of human tE2. The active sites are conserved between prokaryotic tE2 and human tE2. However, marked structural differences are apparent in the hairpin domain and in the N-terminal helix connected to the flexible linker. These permutations away from the catalytic center likely impart structures needed to integrate a second component into the inner core and provide a sturdy base for the linker that holds the pyruvate dehydrogenase for access by the E2-bound regulatory kinase/phosphatase components in humans.
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{{ABSTRACT_PUBMED_18184588}}
==About this Structure==
==About this Structure==
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[[Category: Central beta-sheet surrounded by five alpha-helice]]
[[Category: Central beta-sheet surrounded by five alpha-helice]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:31:13 2008''
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[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 08:48:55 2008''

Revision as of 05:48, 16 July 2008

Image:3b8k.png

Template:STRUCTURE 3b8k

Structure of the Truncated Human Dihydrolipoyl Acetyltransferase (E2)

Template:ABSTRACT PUBMED 18184588

About this Structure

3B8K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains., Yu X, Hiromasa Y, Tsen H, Stoops JK, Roche TE, Zhou ZH, Structure. 2008 Jan;16(1):104-14. PMID:18184588

Page seeded by OCA on Wed Jul 16 08:48:55 2008

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